Wang Zeke | the local resources of market economy concept
An important challenge in modern medicinal chemistry is to develop and utilize various computational approaches to speed up drug discovery process. Prof. Hou's group primarily focuses on the development and application of state-of-art computational and theoretical techniques to investigate the structures, functions, and dynamics of important drug targets and design potential new drugs using computational approaches and chemical/biological experiments. The research directions in Prof. Hou's group are summaried into the following parts:
1. Development of structure-based virtual screening (SBVS) methodologies;
2. Predictions of ADMET and drug-likeness;
3. Discovery and design of small molecular inhibitors of important protein targets;
4. Large-scale simulations of target-ligand recognition.
1. 2013-now Professor, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China.
2. 2009-2013 Professor, Institute of Functional Nano & Soft Materials (FUNSOM), Soochow University, Suzhou, China.
3. 2004-2009 Postdoctor and research scientist, College of Chemistry and Biochemistry, UCSD, USA.
4. 2002-2004 Postdoctor, College of Chemistry and Molecular Engineering, Peking University, Beijing, China.
5. 1997-2002 Ph.D. in Computational Chemistry, College of Chemistry and Molecular Engineering, Peking University, Beijing, China. (Supervisor: Professor Xiaojie Xu)
6. 1992-1997 B.Sc, College of Chemistry and Molecular Engineering, Peking University, Beijing, China. (Supervisor: Professor Xiaojie Xu)
Editors and editorial editors for the following journals: Journal of Cheminformatics, Journal of Chemical Information and Modeling, International Journal of Molecular Sciences (Molecular Informatics Section), Frontiers in Pharmacology (associate editor of Experimental Pharmacology and Drug Discovery Section), Current Pharmaceutical Design, Chemical Biology & Drug Design, Mini-Reviews in Medicinal Chemistry, Theoretical Biology & Medical Modelling, Current Computer-aided Drug Design, Medicinal Chemistry, Computational and Mathematical Methods in Medicine, Genomics, Proteomics & Bioinformatics (2015~2017), Journal of Pharmaceutics, Journal of Molecular Graphics & Modeling, Heliyon.
Guest editors for the following journals:Advanced Drug Delivery Reviews, Current Drug Targets, Evidence-Based Complementary and Alternative Medicine, Combinatorial Chemistry & High Throughput Screening.
Wang Zeke | the local resources of market economy concept
