1994-1997   哥伦比亚大学  生物物理化学  博士PhD
1998-1990   浙江大学  凝聚态物理  硕士MS
1986-1988 浙江大学 物理 学士BS
1984-1986 浙江大学 首届混合班 荣誉学位
 

   浙江大学求是讲席教授，上海高等研究院院长，定量生物中心主任，哥伦比亚大学化学系兼职教授。曾任IBM Watson 研究院软物质科学系主任，IBM蓝色基因计划生命科学首席科学家，杰出研究员。长期从事计算生物学、药物化学、纳米医药与人工智能等交叉学科的研究，在计算+药物设计、蛋白质折叠、肿瘤免疫机制等领域取得了一系列国际领先的原创性成果。拥有或已申请32项国际专利，在国际权威学术刊物发表论文280余篇 (其中32篇发表于Science，Nature，Cell，Nature子刊，PNAS)，文章总引用超过20000余次，H因子73 （Google Scholar）。曾获全美化学学会计算化学奖 (DEC Award)，IBM杰出科技贡献奖 (IBM技术类最高奖)，IBM杰出创新奖, 并于2009年以IBM蓝色基因计划主要成员之一荣获奥巴马总统颁发的美国国家技术奖章(总统奖)。周如鸿教授于2011年当选美国科学促进会会士 (AAAS Fellow)，美国物理学会会士(APS Fellow)，并于2012年入选IBM全球八大研究院“将对IBM，对世界，可能产生最重大影响”的五名科学家之一。周如鸿教授同时担任美国分子科学领域顶尖的Telluride科学研究中心董事会的董事（Board of Directors），和美国芝加哥大学多尺度科学中心的科学顾问（Scientific Advisory Board）。

近年来的代表性工作包括：（1）与合作者首次利用高性能计算与机器学习解决了肿瘤免疫药物在不同人群中有不同响应率之谜，新发现的HLA 基因亚类成为临床免疫药物生物标识；（2）首次发现了I-型糖尿病患者存在新的免疫细胞（X-cell），它同时具有T-cell与B-cell的特性，改写免疫学教科书，并发现这个X-cell具有引发自免疫的超级自抗原，为基于自抗原的免疫疫苗提供了新思路；（3）在抗肿瘤纳米药物，新一代纳米抗生素等方面取得一系列的突破性进展与纳米原药，相关工作发表于 Nature子刊，PNAS等，同时被《MIT Tech Review》列入2012年突破性成果;（4）早年开发的PME/RESPA，REST2等先进采样算法近年来进一步开发并得到广泛应用，扩展至几乎所有商用与开源分子动力学软件；（5）首次提出在生物大分子自组装体系内可能存在一级去浸润相变（Science 2004，Nature 2005), 两年后被实验证实，近年来这一纳米尺度的奇特效应被 Schrodinger 公司（药物设计领域最大的上市公司）应用于药物设计;（6）与麻省总医院合作设计的HIV/AIDS疫苗进入临床前试验，与英国某著名食品公司合作设计的味觉添加剂成为产品并进入市场销售。

代表论文：
1.David R Bell, Jeffrey K Weber, Wang Yin, Tien Huynh, Wei Duan*, Ruhong Zhou*, In silico design and validation of high-affinity RNA aptamers targeting epithelial cellular adhesion molecule dimers, Proc. Natl. Acad. Sci., 117, 8486–8493, 2020
2.Rizwan Ahmed, Zahra Omidian, Adebola Giwa, Benjamin Cornwell, Neha Majety, David R. Bell, Sangyun Lee, Hao Zhang, Aaron Michels, Stephen Desiderio, Scheherazade Sadegh-Nasseri, Hamid Rabb, Mario Suva, Simon Gritsch, Patrick Cahan, R. H. Zhou*, Chunfa Jie, Thomas Donner and Abdel R. Hamad*, Analysis of antigen-receptor sequences of a unique lymphocyte reveals a T cell-neoantigen encoded in a public BCR of T1D patients, Cell, 177, 1583–1599, 2019
3.Binquan Luan*, R. H. Zhou, Spontaneous ssDNA stretching on graphene and hexagonal boron nitride in plane heterostructures, Nature Commun. 10, 4610, 2019
4.Xiaomei Wang, Xing Dai, Cen Shi, Jianmei Wan, Mark A. Silver, Linjuan Zhang, Lanhua Chen, Xuan Yi, Bizheng Chen, Duo Zhang, Kai Yang, Juan Diwu*, Jianqiang Wang, Yujie
5.Xu, R. H. Zhou*, Zhifang Chai, Shuao Wang*, A 3, 2-Hydroxypyridinone-based Decorporation Agent that Removes Uranium from Bones In Vivo, Nature Commun. 10, 2570, 2019
6.Diego Chowell, Luc GT Morris, Claud M Grigg, Jeffrey K Weber, Robert M Samstein, Vladimir Makarov, Fengshen Kuo, Sviatoslav M Kendall, David Requena, Nadeem Riaz, Benjamin Greenbaum, James Carroll, Edward Garon, David M Hyman, Ahmet Zehir, David Solit, Michael Berger, R. H. Zhou, Naiyer A Rizvi, Timothy A Chan, Patient HLA class I genotype influences cancer response to checkpoint blockade immunotherapy, Science, 359, 582-587, 2018
7.Ge Fang, Weifeng Li, Xiaomei Shen, Jose Manuel Perez-Aguilar, Yu Chong, Xingfa Gao, Zhifang Chai, Chunying Chen, Cuicui Ge*, and R. H. Zhou*, Differential Pd-Nanocrystal Facets Demonstrate Distinct Antibacterial Activity against Gram-positive and Gram-negative Bacteria, Nature Communications, 9, 129, 2018
8.Yu Chong, Xing Dai, Ge Fang, Renfei Wu, Lin Zhao, Xiaochuan Ma, Xin Tian, Sangyun Lee, Chao Zhang, Chunying Chen, Zhifang Chai, Cuicui Ge, and R. H. Zhou, Palladium Concave Nanocrystals with High-index Facets Accelerate Ascorbate Oxidation in Cancer Treatment, Nature Communications, 9, 4861, 2018
9.Alok V. Joglekar, Zhe Liu, Jeffrey K. Weber, Yong Ouyang, John D. Jeppson, Won Jun Noh, Pedro A. Lamothe-Molina, Huabiao Chen, Seung-gu Kang, Michael T. Bethune, R. H. Zhou*, Bruce D. Walker, David Baltimore*, HIV-specific T cell receptors from patients with differential immunologic control are functionally indistinguishable, Proc. Natl. Acad. Sci., 115, 1877-1882, 2018
10.through Graphene–MoS2 Heterostructure Nanopores,J. Phys. Chem. Lett.9, 3409–3415, 2018
11.Nana Luo, Jeffrey K. Weber, Shuang Wang, Binquan Luan, Hua Yue, Xiaobo Xi, Jing Du, Zaixing Yang, Wei Wei, R. H. Zhou*, Guanghui Ma*, PEGylated Graphene Oxide Elicits Strong Immunological Responses Despite Surface Passivation, Nature Communications, 8, 14537, 2017
12.T. Zheng, Z. X. Yang, D. Gui, Z. Liu, X. Wang, X. Dai, S. Liu, L. Zhang, Y. Gao, L. Chen, D. Sheng, Y. Wang, J. Diwu, J. Wang, R. H. Zhou*, Z. F. Chai, T. E. Albrecht-Schmitt, and S. Wang*, Overcoming the crystallization and designability issues in the ultrastable zirconium phosphonate framework system, Nature Communications 8, 15369, 2017
13.Y. Li, Z. Yang, Y. Wang, Z. Bai, T. Zheng, X. Dai, S. Liu, D. Gui, W. Liu, M. Chen, L. Chen, J. Diwu, L. Zhu, R. H. Zhou*, Z. Chai, T. E. Albrecht-Schmitt, and S. Wang*, A Robust Mesoporous Cationic Thorium Organic Framework that Rapidly Traps Large Anionic Persistent Organic Pollutants, Nature Communications, 8, 1354, 2017
14.Zhonghe Xu, Yang Sun, Jeffrey K. Weber, Yi Cao, Wei Wang, Daniel Jasinski, Peixuan Guo, R. H. Zhou, and Jingyuan Li, Directional mechanical stability of Bacteriophage ϕ29 motor’s 3WJ-pRNA: extraordinary robustness along portal axis, Science Advances, 3, e1601684, 2017
15.Michael C. Baxa, Wookyung Yu, Aashish N. Adhikari, Liang Ge, Zhen Xia, R. H. Zhou*, Karl F. Freed, Tobin R. Sosnick*, Even with non-native interactions, the updated folding transition states of the homologs Protein G & L are extensive and similar, Proc. Natl. Acad. Sci. 112, 8302-8307, 2015
16.Guillaume Stirnemann, Seung-Gu Kang, R. H. Zhou, and B. J. Berne,How Force Unfolding Differs from Chemical Denaturation, Proc. Natl. Acad. Sci. 111, 3413-3418, 2014
17.Y. Tu, M. Lv, P. Xiu, T. Huynh, M. Zhang, M. Castelli, Z. R. Liu, Q. Huang, C. H. Fan, H. P. Fang, and R. H. Zhou, Destructive Extraction of Phospholipids from E. Coli Membrane by a Graphene Nanosheet, Nature Nanotech. 8, 594-601, 2013
18.B. Dai, S. G. Kang, T. Huynh, H. Z. Lei, M. Castelli, J. Hu, Y. Zhang and R. H. Zhou, Salts Drive Controllable Multi-Layered Upright Assembly of Amyloid-like Peptides at Mica/Water Interface, Proc. Natl. Acad. Sci. 110, 8543-8548, 2013
19.L. Cong, R. H. Zhou, Y. C. Kuo, M. Cunniff, and F. Zhang, Comprehensive Interrogation of Natural TALE DNA Binding Modules and Transcriptional Repressor Domains, Nature Commun. 3, 968, 2012
20.S. G. Kang, G. Q. Zhou, P. Yang, Y. Liu, B. Y. Sun, T. Huynh, H. Meng, L. Zhao, G. M. Xing, C. Y. Chen, Y. L. Zhao, R. H. Zhou, Molecular Mechanism of Pancreatic Tumor Metastases Inhibition by Metallofullerenol Gd@C82(OH)22: Implication for de novo Design of Nanomedicine, Proc. Natl. Acad. Sci., 109, 15431-15436, 2012 (featured article)
21.P. Das, J. A. King, and R. H. Zhou, Aggregation of D-Crystallin Associated with Human Cataracts via Domain Swapping at the C-terminal -strands, Proc. Natl. Acad. Sci. 108, 10514-10519, 2011 (featured article)
22.C. Ge, J. F. Du, L. Zhao, L. Wang, Y. Liu, D. H. Li, Y. Yang, R. H. Zhou, Y. L. Zhao, Z. F. Chai, C. Y. Chen, Binding of human serum proteins on single-wall carbon nanotubes reduces cytotoxicity, Proc. Natl. Acad. Sci, 108, 16968-16973, 2011 (featured article)
23.Y. Tu, P. Xiu, R. Wan, J. Hu, R. H. Zhou and H. Fang, Water-mediated signal multiplication with Y-shaped carbon nanotubes, Proc. Natl. Acad. Sci. 106, 18120-18124, 2009
24.L. Hua, R. H. Zhou, D. Thirumalai, B. J. Berne, Urea denaturation by stronger dispersion interactions with proteins than water implies a 2-stage unfolding, Proc. Natl. Acad. Sci., 105, 16928-16933, 2008 (featured article)
25.J. Li, X. Gong, H. Lu, D. Li, H. Fang and R. H. Zhou, Electrostatic Gating of a Nanometer Water Channel, Proc. Natl. Acad. Sci., 104, 3687-3692, 2007
26.R. H. Zhou, M. Eleftheriou, A. Royyuru, B. J. Berne, Destruction of long-range interactions by a single mutation in lysozyme, Proc. Natl. Acad. Sci., 104, 5824-5829, 2007
27.P. Liu, X. Huang, R. H. Zhou and B. J. Berne, Observation of a dewetting transition in the collapse of melittin tetramer, Nature, 437, 159-162, 2005
28.R. H. Zhou, X. Huang, C. Margulius and B. J. Berne, Hydrophobic Collapse in Multi-domain Protein Folding, Science, 305, 1605-1609, 2004
29.R. H. Zhou, Trp-cage: Folding Free Energy Landscape in Explicit Water, Proc. Natl. Acad. Sci., 100, 13280-13285, 2003
30.R. H. Zhou and B. J. Berne, Can a continuum solvent model reproduce the free energy landscape of a beta-hairpin folding in water?, Proc. Natl. Acad. Sci. 99, 12777-12782, 2002
31.R. H. Zhou, B. J. Berne and R. Germain, Free energy landscape of a beta-hairpin folding in explicit water, Proc. Natl. Acad. Sci. 98, 14931-14936, 2001

个人主页  https://person.zju.edu.cn/ruhong